How Your Genes Impact Focus, Energy, and Mental Performance

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You’ve optimized sleep, dialed in your supplements, and fine-tuned your habits. But something still feels off.

If you’re constantly battling brain fog, energy crashes, or slow thinking—your genetics might be working against you.

Certain gene variants can drain mental energy, slow neurotransmitter production, and sabotage motivation.

The good news? You don’t have to just deal with it.

Here’s how to identify genetic bottlenecks and fix them for peak cognitive performance.

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Low Energy & Mental Fatigue?

🧬 Genetic Culprit: NDUFS3, MTCH2 (Mitochondrial Dysfunction)

Mitochondria are your cells’ power plants.

If these genes aren’t functioning well, your brain doesn’t get the energy it needs—leaving you mentally sluggish, foggy, and drained by mid-afternoon.

Symptoms of Mitochondrial Dysfunction:

• Mental crashes after short periods of work

• Brain fog and trouble processing information

• Physical exhaustion even with solid sleep

How to Fix It:

• Creatine Monohydrate (3-5g/day) – Fuels ATP production for brain energy.

• CoQ10 (100-200mg/day) – Essential for mitochondrial function.

• Alpha Lipoic Acid (300mg/day) – Supports cellular energy metabolism.

• Cold Exposure – Forces mitochondria to become more efficient.

Test It: If your energy levels improve, your mitochondria were likely the issue.

Feeling Mentally Slow?

🧬 Genetic Culprit: CHRNA4, CHAT (Low Acetylcholine)

Acetylcholine is the neurotransmitter responsible for fast thinking, memory recall, and cognitive flexibility.

If your genes don’t produce enough, you might feel slow, forgetful, or struggle to process information.

Symptoms of Low Acetylcholine:

• Forgetting names, words, or details in conversations

• Slow reaction time in meetings or high-pressure decisions

• Trouble multitasking or switching between tasks efficiently

How to Fix It:

• Alpha-GPC or CDP-Choline (300-600mg/day) – Direct acetylcholine support.

• Huperzine A (50-200mcg/day) – Prevents breakdown of acetylcholine.

• Eggs, Fish, Beef Liver – Natural dietary sources of choline.

Test It: If you notice sharper memory and faster thinking, acetylcholine was likely the issue.

Struggling with Motivation & Drive?

🧬 Genetic Culprit: COMT, DRD4 (Dopamine Sensitivity)

Dopamine drives motivation, focus, and goal-setting.

If your genes clear dopamine too quickly or don’t respond well to it, you might feel unmotivated, distracted, or dependent on high-stimulation activities to stay engaged.

Symptoms of Low Dopamine Sensitivity:

• Lack of motivation even when well-rested

• Needing caffeine, novelty, or risk-taking to feel engaged

• Struggling to stay excited about long-term goals

How to Fix It:

• L-Tyrosine (500mg-1g/day) – Precursor to dopamine production.

• Mucuna Pruriens (100-300mg/day) – Provides direct L-Dopa.

• Rhodiola Rosea (250mg/day) – Balances dopamine release for steady focus.

Test It: If your drive and motivation increase, dopamine sensitivity was the issue.

Overthinking, Anxious, or Stressed?

🧬 Genetic Culprit: Slow COMT Gene (Dopamine Clearance Issues)

If you break down dopamine too slowly, it can lead to overanalyzing, anxiety, and perfectionism.

Instead of boosting dopamine, you need to clear it more efficiently.

Symptoms of Slow Dopamine Clearance:

• Overthinking decisions and struggling to take action

• Feeling anxious under pressure

• Inability to “shut off” your brain at night

How to Fix It:

• Magnesium L-Threonate (1-2g/day) – Helps regulate dopamine levels.

• Green Tea (EGCG, 1 cup/day) – Aids dopamine breakdown for balanced focus.

• Mindfulness & Box Breathing – Reduces cognitive overload.

Test It: If your anxiety drops and mental clarity improves, dopamine breakdown speed was the issue

Want to Be 100% Sure?

Your brain is your business’s operating system—but most entrepreneurs rely on generic advice without knowing if it’s working for their biology.

That’s why I created a gene-based cognitive optimization audit—built specifically for entrepreneurs.

No random data. No guesswork.

Just precise, science-backed steps to enhance focus, energy, and decision-making.

Why This is Different

• Find Your Cognitive Bottlenecks: Pinpoint the exact genetic factors slowing you down—so you can think faster, focus longer, and sustain energy all day.

• No Guesswork, Just Clarity: Instead of generic reports, you’ll get a done-for-you blueprint with specific, actionable steps.

• Time-Efficient: No wasting months experimenting with random supplements or habits. Get direct, personalized solutions from the start.

• Entrepreneur-Optimized: This isn’t about general health—it’s built for decision-makers who need peak cognitive performance.

I’m opening early access to a 20 person group before launch.

This will be a hands-on, high-level experience, so I’m looking for people serious about optimizing their brain for peak performance. 

Reply “Gene” to this email if you want in.

If you want a solid alternative, here are good options:

- SelfDecode – Personalized cognitive and health insights.
- Dante Labs – Full genome sequencing with deep trait analysis.
- 23andMe + Promethease – Upload raw DNA for third-party interpretation.

Final Thought: Your Brain is Your Business’s Greatest Asset

Your cognitive performance is your competitive edge.

Start today: Pick one issue, test the recommended fixes for two weeks, and track your results.

Small changes compound into massive advantages.

But if you’re serious about precision-based cognitive upgrades, join the waitlist.

Your business moves at the speed of your brain—make sure it’s running at full capacity.

Talk soon,

Dalton

P.S: Next Wednesday, how to engineer breakthroughs on command with science. See you then!

Explore Further:

• Understanding Genetic Testing, Proper Nutrition, and Supplements - Gary Brecka